Samples are collected at the point-of-care and sent to a lab. Within 3 to 5 days after lab receives the pod, results are available for download from a secure website. This pod is a combo test for women and includes TSH, IgE, and hs-CRP levels.
Professional use only
Pods must be drop-shipped from PTS Diagnostics.
Account with CoreMedical Labs is necessary.
CoreMedical Labs will send pre-printed/bar coded requisition forms.
The PTS Pod system offers a variety of different lab-based tests. The thyroid-stimulating hormone (TSH) test is often the test of choice for evaluating thyroid function and/or symptoms of a thyroid disorder, including hyperthyroidism or hypothyroidism. The total IgE test may be used to screen for and detect allergic diseases. It may be ordered by itself, before, or along with allergen-specific IgE tests – depending upon whether or not a person or doctor has identified potential substances to which the person may be allergic. IgE can be increased with parasitic infections, so a total IgE test is sometimes used as a screening test if a parasitic infection is suspected. A high-sensitivity C-reactive protein (hs-CRP) test may be used to help evaluate an individual for risk of cardiovascular disease (CVD). It may be used in combination with a lipid profile or with other cardiac risk markers, such as a lipoprotein-associated phospholipase A2 (Lp-PLA2) test, to provide added information about heart disease risk.
A health practitioner may order a TSH test when someone has symptoms of hyperthyroidism or hypothyroidism and/or when a person has an enlarged thyroid gland (goiter).TSH may be ordered at regular intervals when an individual is being treated for a known thyroid disorder. When a person's dose of thyroid medication is adjusted, the American Thyroid Association recommends waiting 6-8 weeks before testing the level of TSH again. TSH screening is routinely performed in the United States on newborns soon after birth as part of each state's newborn screening program. In 2004, the U.S. Preventive Services Task Force found insufficient evidence to recommend for or against routine screening for thyroid disease in asymptomatic adults. However, the American Thyroid Association and the American Association of Clinical Endocrinologists released clinical practice guidelines in 2012 that recommend that screening for hypothyroidism should be considered in people over the age of 60. Because the signs and symptoms of both hypothyroidism and hyperthyroidism are so similar to those seen in many common disorders, health practitioners often need to rule out thyroid disease even though the patient has another problem.
Currently, there is no consensus on when to get tested, though some guidelines include recommendations on hs-CRP testing. For example, a guideline from the American College of Cardiology Foundations and the American Heart Association says that hs-CRP testing may be useful when men 50 years old or younger and women 60 years old or younger have intermediate risk. It also may be useful for treatment decisions when men and women are older than these respective ages and have LDL-C less than 130 mg/L and meet several other criteria, such as no existing heart disease, diabetes, kidney disease, or inflammatory conditions.
When hs-CRP is evaluated, it may be repeated to confirm that a person has persistent low levels of inflammation.
It is important that any person having this test be in a healthy state for the results to be of value in predicting the risk of coronary disease or heart attack. Any recent illness, tissue injury, infection, or other general inflammation will raise the amount of CRP and give a falsely elevated estimate of risk.
Women on hormone replacement therapy have been shown to have elevated hs-CRP levels.
Since the hs-CRP and CRP tests measure the same protein, people with chronic inflammation, such as those with arthritis, should not have hs-CRP levels measured. Their CRP levels will already be very high due to the arthritis, so results of the hs-CRP test will not be meaningful.
A total IgE test may be ordered when a person has periodic or persistent symptoms that may be due to an allergic reaction, especially when the potential allergen is unknown. Symptoms may include those that suggest skin, respiratory, and/or digestive involvement, such as:
Sometimes an IgE may be ordered as a screening test when a person has persistent diarrhea that may be due to a parasitic infection. In addition, a CBC with white blood cell differential may be ordered to determine if the number of eosinophils is increased. In order to identify specific allergies, a doctor must order tests that detect allergen-specific IgE. If a person is suspected of having an allergy to cats, then a cat dander IgE test must be ordered. If the person actually has an allergy to dogs, it will not be detected with this test. For this reason, doctors may screen with a total IgE test, then run panels of substance-specific IgE tests. These panels may include a range of common allergens or similar types of allergens, such as various grasses, pollen, molds, pet dander, and/or foods.
A person's symptoms during an allergic episode do not necessarily correlate with their total IgE level.
Infrequently, an IgE test may be ordered to help diagnose a very rare inherited disease called hyperimmunoglobulin E syndrome (Job syndrome). People with this disease often have significantly higher than normal IgE levels and may have eczema, recurrent sinus and lung infections, bone defects, and severe skin infections. A greatly increased IgE concentration may indicate that an individual has inherited this condition. Additional testing can be performed to detect a mutation in the STAT3 gene that has been associated with this disorder.
Rarely, the IgE test is used to help diagnose and monitor multiple myeloma that produces monoclonal IgE.
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