|
Reason |
Total Cholesterol |
HDL |
Triglycerides |
Direct LDL |
Calculated LDL
LDL=TC-HDL-Trig/5 |
| Use
improper blood collection techniques for PTS lipid panel |
Can cause large variations (See Rules, Procedures, Common
Mistakes) |
|
Season-to-season (winter is highest) |
Varies up to 12% |
|
|
|
|
| Day-to-day
variation |
Varies 3-5% |
|
Varies 20-30% |
|
|
|
As age increases |
Increases |
|
Increases |
|
Increases |
| Recommend
posture (sit for at least 5 min) |
Decreases 10-15% |
|
|
|
|
| Tourniquet
for venous sample (applied 2 min) |
Increase 2-5% |
|
|
|
|
| Tourniquet
for venous sample (applied 5+ min) |
Increase 10-15% |
|
|
|
|
|
Anticoagulant (fluoride,citrate,oxulate) |
Decrease 10% |
|
|
|
|
| Blood
sampling method |
Finger prick samples are 2-4% higher than venous blood
sample |
| Test
without 8-12 hour fasting (12 hrs is optimal) |
|
|
Not accurate |
|
|
|
Triglycerides <= 250 mg/dL |
|
|
|
|
Most accurate |
| 250 mg/dL<Triglycerides<400
mg/dL |
|
|
|
|
Less accurate |
|
Triglycerides>=400 mg/dL |
|
|
|
|
Not accurate |
|
Clinic-to-clinic variation |
|
|
|
Varies up to
12% |
| Measured
vs. Calculated LDL on Cardiochek |
|
|
|
Direct LDL is
3-4% lower than calculated LDL |
| Maintain
normal diet for 2 weeks |
Stabilizes all
types of cholesterol measurements |
| Maintain
stable weight for 2 weeks |
Stabilizes all
types of cholesterol measurements |
| Excess
dietary fat, cholesterol, calories |
Tends to
increase all types of cholesterol measurements |
| Alcohol
consumption |
|
Increases |
Increases |
|
|
| Exercise |
|
Increases |
Decreases |
Decreases |
Decreases |
| High blood
pressure medicine |
|
Decrease |
Increase |
|
|
| Birth
control pills |
Decrease |
Increase |
|
|
|
| Up to 8
weeks after heart attack or stroke |
Falls considerably |
|
Rises considerably |
|
|
| Up to 8
weeks after trauma or acute infection |
Falls up to 40% |
|
|
|
|
| Pregnancy |
Increase 20-35% |
|
|
Increase |
Increase |
| Resistance
to insulin |
|
Decrease |
Increase |
|
|
| Metabolic
Syndrome |
|
Decrease |
Increase |
|
|
| Type 2
Diabetes |
|
Decrease |
Increase |
|
|
|
Hyperthyroidism |
Decrease |
|
|
|
|
|
Hypothyroidism |
Increase |
|
|
|
|
| Liver
disease |
Varies considerably |
|
|
|
|
| Renal
failure |
Varies considerably |
|
|
|
|
|
Malnutrition |
Decrease |
|
|
|
|
